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The results suggest that bilirubin exerts a protective effect in intrinsic immune-related inflammation at certain doses by a mechanism associated with the NF-B signaling pathway inhibition and the NOD-like receptor family CARD domain-containing protein 4 (NLRC4) activation, Absent in Melanoma 2 (AIM2), and NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammatory vesicles, of which the inhibition contributes to the control of cancer (9294)